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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T24067 | Flt3 Inhibitor IV | Flt3 Inhibitor-IV,Flt3-IN-IV | |
Flt3 Inhibitor IV is a potent ATP-competitive Flt3 inhibitor. | |||
T11299 | FLT3-IN-4 | FLT3 inhibitor 9u | FLT |
FLT3-IN-4 (FLT3 inhibitor 9u) is a potent and orally effective Fms-like tyrosine receptor kinase 3 (FLT3; IC50=7 nM) inhibitor ,for treating acute myelogenous leukemia. | |||
T6138 | TCS 359 | FLT3 Inhibitor | FLT |
TCS 359 (FLT3 Inhibitor) is a potent FLT3 inhibitor with IC50 of 42 nM. | |||
T1938 | FLT3-IN-2 | FLT | |
FLT3-IN-2 is an FLT3 inhibitor (IC50<1 μM). | |||
T11298 | FLT3-IN-3 | FLT | |
FLT3-IN-3 is an effective FLT3 inhibitor, and the IC50s of FLT3 WT and FLT3 D835Y are 13 and 8 nM, respectively. | |||
T2051 | SKLB4771 | FLT3-IN-1,FLT3-IN-1 | FLT |
SKLB4771 (FLT3-IN-1) is a novel potent and selective Flt3 inhibitor. | |||
T38562 | AKN-028 | FLT | |
AKN-028 is an orally active and potent FLT3 tyrosine kinase inhibitor ( IC 50 = 6 nM). AKN-028 causes dose-dependent inhibition of FLT3 autophosphorylation. | |||
T2340 | AC1NS4RE | Tyrosinase | |
It is a tyrosine kinase inhibitor. | |||
T4428 | CCT241736 | FLT , Aurora Kinase | |
CCT241736 is an orally bioavailable dual FLT3/Aurora kinase inhibitor that also inhibits clinically relevant FLT3-resistant mutants including FLT3-ITD and FLT3, CCT241736, an advanced analog of CCT137690, is a preclinica... | |||
T2066 | Quizartinib | AC220 | Apoptosis , FLT , Autophagy , Ligands for Target Protein for PROTAC |
Quizartinib (AC220) is an inhibitor of FLT3 (Kd: 1.6 nM) and demonstrates high selectivity for FLT3 when tested against a panel of 227 additional kinases. | |||
T15335 | FN-1501 | FLT , CDK | |
FN-1501 is a potent FLT3 and CDK inhibitor (IC50s: 2.47, 0.85, 1.96, and 0.28 nM for CDK2/cyclin A, CDK4/cyclin D1, CDK6/cyclin D1 and FLT3, respectively). FN-1501 also has anticancer activity. | |||
T2272 | BPR1J-097 | BPR1J097 | FLT |
BPR1J-097) is a novel FLT-3 inhibitor(IC50: 11±7 nM) with promising in vivo anti-tumor activities. It also inhibits FLT-3 D835Y (IC50: 3 nM). | |||
T6756 | AMG 925 | FLT , CDK | |
AMG 925 is a potent and orally bioavailable dual FLT3/CDK4 inhibitor with IC50 of 1 nM and 3 nM, respectively. | |||
T7673 | ATH686 | ATH 686 | Apoptosis , FLT |
ATH686 is an potent and selective Inhibitor of FLT3. | |||
T9473 | 4SC-203 | FLT | |
4SC-203 is a multikinase inhibitor with potential antineoplastic activity. 4SC-203 selectively inhibits FMS-related tyrosine kinase 3 (FLT3/STK1), FLT3 mutated forms, and vascular endothelial growth factor receptors (VEG... | |||
T3065 | TG101209 | Apoptosis , FLT , c-RET , JAK , Autophagy | |
TG101209 is a selective JAK2 inhibitor with IC50 of 6 nM. | |||
T24438 | MDK5466 | MDK-5466,MDK 5466,E21,Flt3-IN-III,Flt3 Inhibitor III | |
MDK5466 is an Flt3 inhibitor that acts by preventing glutamate-induced cell death. | |||
T6020 | Pacritinib | SB1518 | FLT , Tyrosine Kinases , JAK |
Pacritinib (SB1518) (SB1518) is an effective and specific inhibitor of JAK2 and FLT3 (IC50: 23/22 nM, in cell-free assays). | |||
T8317 | 5'-Fluoroindirubinoxime | 5'-FIO | FLT |
5'-Fluoroindirubinoxime (5'-FIO) is a potent FLT3 inhibitor( IC50 : 15 nM). | |||
TQ0235 | AC710 | FLT , PDGFR , c-Kit | |
AC710 is a potent PDGFR inhibitor (Kds: 0.6, 1, 1.57, 1.3, 1 nM for FLT3, KIT, CSF1R, PDGFRα and PDGFRβ). |